LNP Systems

designed for
METHOD DEVELOPMENT AND SCALE-UP
✔ Scale-up with 5 IJMs
✔ Encapsulation at a range of
✔ 500 µL to hundreds of milliliters
✔ Small-scale production up to 70 mL/min

INCLUDES
✔ 5 KNAUER IJMs
✔ 3 pumps
✔ 2 valves
✔ 3 different API sample loops

designed for
METHOD DEVELOPMENT AND SCALE-UP
✔ Scale-up with 5 IJMs
✔ Encapsulation at a range of
✔ 500 µL to hundreds of milliliters
✔ Small-scale production up to 70 mL/min

INCLUDES
✔ 5 KNAUER IJMs
✔ 3 pumps
✔ 2 valves
✔ 3 different API sample loops

designed for
AUTOMATED SCREENING AND SCALE-UP
✔ High-throughput screening with up to 108 samples
✔ Automated premix of different lipid compositions to screen early-stage API candidates
✔ Minimal sample volume of 300 µL
✔ up to 70 mL/min

INCLUDES
✔ 5 KNAUER IJMs
✔ 3 pumps
✔ one Autosampler with cooling option
✔ UV detector

designed for
AUTOMATED SCREENING AND SCALE-UP
✔ High-throughput screening with up to 108 samples
✔ Automated premix of different lipid compositions to screen early-stage API candidates
✔ Minimal sample volume of 300 µL
✔ up to 70 mL/min

INCLUDES
✔ 5 KNAUER IJMs
✔ 3 pumps
✔ two Autosampler with cooling option
✔ UV detector

designed for
CLINICAL TRIALS
✔ Compact, GMP-ready design for benchtop use in labs or clinical trials
✔ From concept to clinic: Supports development, scale-up, and GMP batch production
✔ LNP formulation up to 700 mL/min INCLUDES
✔ 3 KNAUER IJMs
✔ 3 pumps
✔ Benchtop module with one flowmeter, PC, switch, valves and mixers

designed for
COMMERCIAL PRODUCTION
✔ API predilution
✔ Online flow and pressure monitoring
✔ Large-scale production up to 1 L/min

INCLUDES
✔ 1 KNAUER IJM
✔ 4 pumps
✔ 4 flowmeters
✔ 1 valve
✔ GMP ready documentation
✔ 21 CFR part 11 and GAMP 5 compliant software

designed for
LARGE-SCALE COMMERCIAL PRODUCTION
✔ Parallel LNP formulation with 2 KNAUER IJMs
✔ Online flow and pressure monitoring
✔ Large-scale production up to 2 L/min

INCLUDES
✔ 2 KNAUER IJMs
✔ 8 pumps
✔ 8 flowmeters
✔ 2 valves
✔ GMP ready documentation
✔ 21 CFR part 11 and GAMP 5 compliant software

Upgrade Kit for the IJM NanoScaler
✔ Additional sample loop - minimizes sample consumption
✔ Ideal for R&D-scale experiments

INCLUDES
✔ 1 Valve
✔ 1 Set Capillaries IJM NanoScaler Upgrade Kit Lipid Loop

Upgrade Kit for the IJM NanoScaler
✔ Eluent heater with two independent heat channels
✔ Controls fluid temperature up to 100 °C (212°F)

INCLUDES
✔ 1 AZURA® ELH 2.1L High-Flow Eluent Heater Duo Channel
✔ 1 Set Capillaries IJM NanoScaler Upgrade Kit eTC

Upgrade Kit for the IJM NanoScaler
✔ High-throughput screening with up to 108 samples
✔ Automated premix of different lipid compositions to screen early-stage API candidates

INCLUDES
✔ 1 Autosampler with cooling option
✔ 1 UV detector
✔ 1 AZURA® FC 6.1 BIO Fraction Collector
✔ 1 Set Capillaries IJM NanoScaler Pro Upgrade Kit

Upgrade Kit for the IJM NanoScaler Pro
✔ Full automation for high-throughput workflows and complex libraries
✔ Reduces manual handling, increases process efficiency

INCLUDES
✔ 1 Autosampler with cooling option
✔ 1 Set Capillaries IJM NanoScaler Ultra Upgrade Kit

Upgrade Kit for the IJM NanoScaler
✔ Coriolis flowmeter with integrated temperature and density measurements
✔ PID control enables automatic flow adjustment

INCLUDES
✔ 3 Coriolis flowmeter (M13)
✔ 1 Set Capillaries IJM NanoScaler Upgrade Kit Flowmeter

Upgrade Kit for the IJM NanoScaler
✔ Enables real-time fractionation
✔ Assists with CIP validation

INCLUDES
✔ 1 UV detector
✔ 1 Set Capillaries IJM NanoScaler Upgrade kit UV-Detector

Upgrade Kit for the IJM NanoScaler
✔ Enables real-time fractionation
✔ Assists with CIP validation

INCLUDES
✔ 1 Conductivity monitor
✔ 1 Set Capillaries IJM NanoScaler Upgrade kit Conductivity monitor

Upgrade Kit for the IJM NanoScaler
✔ Fraction collection up to 165 samples per rack
✔ Enables precise inline fractionation
INCLUDES
✔ 1 AZURA® FC 6.1 BIO Fraction Collector
✔ 1 Set Capillaries IJM NanoScaler Upgrade kit Fraction collector

Upgrade Kit for the IJM NanoScaler
✔ Upgrade to stainless steel (SST) capillaries
✔ Improved chemical resistance and cleanability
✔ Ideal for GMP environments and sensitive LNP formulations

INCLUDES
✔ 1 Set Capillaries IJM NanoScaler Upgrade kit SST capillaries

Upgrade Kit for the IJM NanoScaler
✔ Up to 38 mL/min with each pump
✔ Small batch production after process optimization

INCLUDES
✔ 3 High-Flow pump head inlets for the IJM NanoScaler

Accessory for the IJM NanoScaler
✔ Complete capillary replacement kit
✔ All screw fittings included

INCLUDES
✔ 1 Set of capillaries for the IJM NanoScaler (with screw fittings)

Accessory for the IJM NanoScaler
✔ Capillary replacement for the IJM NanoScaler
✔ Reuse existing screw fittings

INCLUDES
✔ 1 Set of capillaries for the IJM NanoScaler (without screw fittings)

Accessory for the IJM NanoScaler
✔ Reduces hold-up volume in the inlet tubing of API/lipid
✔ Enables encapsulation of small batches by direct flow delivery

INCLUDES
✔ 5 Sets of API/lipid supply

Accessory for the IJM NanoScaler
✔ Capillary replacement for the Lipid Loop Upgrade kit
✔ All screw fittings included

INCLUDES
✔ 1 Set of capillaries for the IJM NanoScaler Upgrade kit Lipid Loop (with screw fittings)

Accessory for the IJM NanoScaler
✔ Capillary replacement for the Lipid Loop Upgrade kit
✔ Reuse existing screw fittings

INCLUDES
✔ 1 Set Capillaries IJM NanoScaler Upgrade kit Lipid Loop (without screw fittings)